| Thời gian | Vòng | FT | HT | |||
| Thứ tư, Ngày 18/05/2022 | ||||||
| 18/05 00:00 | 38 | Viktoria Aschaffenburg | 3-2 | Schweinfurt 05 FC | (1-2) | |
| Chủ nhật, Ngày 15/05/2022 | ||||||
| 15/05 20:00 | 10 | FC Hansa Luneburg | 0-3 | St Pauli II | (0-2) | |
| 15/05 19:00 | 9 | FC Teutonia 05 | 6-1 | SV Atlas Delmenhorst | (3-1) | |
| 15/05 19:00 | 10 | Eintracht Norderstedt | 0-0 | HSC Hannover | (0-0) | |
| 15/05 18:00 | 38 | Berliner AK 07 | 7-5 | FSV Optik Rathenow | (3-1) | |
| 15/05 18:00 | 38 | Tennis Borussia Berlin | 3-0 | VfB Auerbach | (2-0) | |
| 15/05 18:00 | 38 | Eilenburg | 2-3 | Hertha BSC Berlin Youth | (1-2) | |
| 15/05 18:00 | 38 | FSV Union Furstenwalde | 1-0 | Carl Zeiss Jena | (1-0) | |
| 15/05 18:00 | 38 | FC Lokomotive Leipzig | 3-1 | FSV luckenwalde | (2-0) | |
| 15/05 18:00 | 38 | VSG Altglienicke | 2-4 | Berliner FC Dynamo | (1-2) | |
| 15/05 18:00 | 38 | Chemnitzer | 5-0 | SV Tasmania Berlin | (1-0) | |
| 15/05 18:00 | 38 | ZFC Meuselwitz | 1-1 | SV Babelsberg 03 | (0-0) | |
| 15/05 18:00 | 38 | Energie Cottbus | 4-1 | BSG Chemie Leipzig | (3-1) | |
| 15/05 18:00 | 38 | Germania Halberstadt | 2-1 | Lichtenberg 47 | (0-0) | |
| Thứ bảy, Ngày 14/05/2022 | ||||||
| 14/05 20:00 | 10 | BSV Rehden | 1-1 | SV Drochtersen/Assel | (1-1) | |
| 14/05 20:00 | 10 | FC Oberneuland | 3-1 | Heider SV | (0-0) | |
| 14/05 20:00 | 10 | SSV Jeddeloh | 2-0 | Altona 93 | (0-0) | |
| 14/05 19:15 | 38 | Rot-Weiss Koblenz | 0-1 | SG Sonnenhof Grossaspach | (0-0) | |
| 14/05 19:00 | 38 | Rot-Weiss Essen | 2-0 | Rot-Weiss Ahlen | (1-0) | |
| 14/05 19:00 | 38 | SV Straelen | 1-4 | SV Rodinghausen | (0-2) | |
| 14/05 19:00 | 38 | Kickers Offenbach | 4-0 | FSV Frankfurt | (2-0) | |
| 14/05 19:00 | 38 | TSV Schott Mainz | 3-0 | Bahlinger | (1-0) | |
| 14/05 19:00 | 38 | Astoria Walldorf | 0-2 | Vfr Aalen | (0-2) | |
| 14/05 19:00 | 37 | SpVgg Bayreuth | 2-1 | Viktoria Aschaffenburg | (1-0) | |
| 14/05 19:00 | 38 | VFB Homberg | 0-0 | Alemannia Aachen | (0-0) | |
| 14/05 19:00 | 38 | TSV Aubstadt | 9-1 | SV Schalding Heining | (5-0) | |
| 14/05 19:00 | 38 | Preuben Munster | 2-1 | Koln Am | (0-1) | |
| 14/05 19:00 | 38 | Fortuna Dusseldorf (Youth) | 0-0 | Monchengladbach AM. | (0-0) | |
| 14/05 19:00 | 38 | TSG Hoffenheim (Youth) | 0-2 | TSV Steinbach Haiger | (0-2) | |
| 14/05 19:00 | 37 | Unterhaching | 2-0 | TSV Rain Am Lech | (1-0) | |
| 14/05 19:00 | 37 | VfB Eichstatt | 1-0 | FC Augsburg II | (1-0) | |
| 14/05 19:00 | 37 | SV Heimstetten | 1-2 | SC Eltersdorf | (1-0) | |
| 14/05 19:00 | 37 | Schweinfurt 05 FC | 1-2 | FV Illertissen | (1-1) | |
| 14/05 19:00 | 38 | Wuppertaler | 4-1 | Wegberg-Beeck | (3-0) | |
| 14/05 19:00 | 38 | SSV Ulm 1846 | 3-2 | VfB Stuttgart II | (1-1) | |
| 14/05 19:00 | 9 | Werder Bremen (Youth) | 2-0 | Holstein Kiel II | (2-0) | |
| 14/05 19:00 | 38 | Fortuna Koln | 2-1 | Sportfreunde Lotte | (1-0) | |
| 14/05 19:00 | 38 | SV Lippstadt | 3-4 | Uerdingen KFC 05 | (3-3) | |
| 14/05 19:00 | 38 | Bonner | 1-5 | Rot-Weiss Oberhausen | (1-2) | |
| 14/05 19:00 | 38 | SV Elversberg | 2-0 | FC 08 Hombrug | (1-0) | |
HT: Tỷ số hiệp 1 (Half-time) | FT: Tỷ số cả trận (Full-time)
